Cytoclear is a newly developed product (consisting of a mixture of protein detergents) which can quickly dissolve and remove persistent cytoplasm (mainly caused by inadequate hypotonic treatment) during the methanol: acetic acid fixation stage of the chromosome harvesting procedure. In particular, it dissolves the lipid and glycoprotein structure of which cytoplasm is mainly composed of. Poor clumped metaphases that would be impossible to analyze can now be saved.  Cytoclear is highly recommended for FISH applications.